منابع مشابه
Kidney-specific Sonoporation-mediated Gene Transfer
Sonoporation can deliver agents to target local organs by systemic administration, while decreasing the associated risk of adverse effects. Sonoporation has been used for a variety of materials and in a variety of organs. Herein, we demonstrated that local sonoporation to the kidney can offer highly efficient transfer of oligonucleotides, which were systemically administrated to the tubular epi...
متن کاملKidney-specific transposon-mediated gene transfer in vivo
Methods enabling kidney-specific gene transfer in adult mice are needed to develop new therapies for kidney disease. We attempted kidney-specific gene transfer following hydrodynamic tail vein injection using the kidney-specific podocin and gamma-glutamyl transferase promoters, but found expression primarily in the liver. In order to achieve kidney-specific transgene expression, we tested direc...
متن کاملKidney-specific gene targeting.
Gene targeting in mice is a powerful tool for identifying the in vivo functions of proteins and for producing new animal models of human diseases. In the conventional approach, the gene encoding a protein of interest is disrupted by homologous recombination in embryonic stem (ES) cells. Targeted ES cells are injected into blastocysts to produce chimeric mice, which are then bred to produce knoc...
متن کاملGene transfer in the kidney.
Gene transfer approaches offer the promise of revolutionizing medicine. In this review, we focus on the current and future prospects of somatic gene transfer into the kidney. The advantages and disadvantages of current vector systems are described, and the ex vivo and in vitro approaches applicable to the kidney are reviewed. We discuss uses of gene transfer approaches to dissect the pathogenes...
متن کاملNeuronal birthdate-specific gene transfer with adenoviral vectors.
The multilayered structure of the cerebral cortex has been studied in detail. Early-born neurons migrate into the inner layer and late-born neurons migrate into more superficial layers, thus establishing an inside-out gradient. The progenitor cells appear to acquire layer-specific properties at the time of neuronal birth; however, the molecular mechanisms of cell-fate acquisition are still uncl...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1997
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)89446-0